[Mikoto was already aware that Sasuke was gone but not that Naruto was as well, which she can imagine is affecting both Minato and Kushina too. She doesn't really know Sakura all that well other than that she was teammates with both Sasuke and Naruto but she can tell this is difficult for her too even with announcing it so if anything Mikoto is more concerned about her right now instead]
Thank you letting us know, Sakura. How are you holding up?
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Thank you letting us know, Sakura. How are you holding up?